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by Carlos Eduardo Espinal

An important decision that companies often ask when starting a company outside of the USA is ‘where should I incorporate?’.

The reason why this question comes up is often because there are a series of benefits pulling founders in different directions and many times founders can receive conflicted advice from well-intending advisors. Some of the issues that founders may be balancing as part of a decision on where to incorporate include things like tax implications (tax breaks or penalties), local grants, and paperwork.This is particularly the case when they are also thinking that the USA might be where they will end up in the future.

Therefore, the purpose of this post is to identify WHAT ISSUES to think about when making the decision so that you can feel more confident about it and it is NOT about recommending a specific jurisdiction to incorporate.

Let’s start by stating that, for the most part, incorporation decisions aren’t necessarily permanent. Yes, there are cases where you make things increasingly hard for you to ‘flip’ your company (flip = taking your company from one legal jurisdiction to another), but for the most part, you can almost always find a way to move your company later if it benefits you to do so. Generally, the cost of doing this will be proportional to the complexity and legal jujitsu your lawyers will have to do in order to make this happen (more on this later). So while not permanent, worth considering all options before taking the easiest or most obvious choice.

Now that you perhaps feel a bit more ‘relieved’ about the not-so-permanent nature of your decision, let’s look at some key factors to consider which will affect your decisions down the road:

1) Tax implications Tax treaties – One of the key things that can really impact your personal returns and that of your investors, now and in the future, is whether there will be a tax impact to you (and your employees and co-founders). Consider things such as tax relief on returns as a founder or if you flip to a different geography in the future. Consider income tax liabilities as well as Womens 29403 Sling Back Sandals Silver Tamaris QVpPS
liabilities ( note: links are to UK site, but there for definitions, which are universal ). Additionally, for potential future investors, consider whether your local jurisdiction has a negative tax impact further down the line for them. These questions can sometimes be answered by tax specialists within your lawyer’s firm (particularly if your law firm has offices abroad) or your accountants.

Tax implications Tax treaties

2) Investor implications – As mentioned above, one reason why the jurisdiction of choice matters is because investors are optimising around what they know their tax implications are, but additionally, there are other matters in the final legal docs which they may prefer dealing with in their local jurisdiction rather than in new ones they are less familiar with. Additionally, they may have a preference where you incorporate due to tax relief they may receive as part of investing in your company. Company governance may also be affected by where you are incorporated. Certain company governance structures are enforced on your company depending on where you incorporate and investors may have an opinion on that one way or another.

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The tangled history over the genome-editing tool has played out in court and scientific circles

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One of the world’s richest science awards, given only in alternate years, will go to three discoverers of the CRISPR-Cas9 genome-editing tool, the Norwegian Academy of Science and Letters announced on Thursday. Emmanuelle Charpentier of the Max Planck Institute for Infection Biology, Jennifer Doudna of the University of California, Berkeley, and Virginijus Šikšnys of Vilnius University will each receive a gold medal and share the $1 million that comes with the Kavli Prize in nanoscience (there are also Kavli prizes for astrophysics and neuroscience).

It was only the latest verdict on the controversial question of who deserves credit for turning a bacterial immune system into a revolutionary genome-editing tool. As multiple companies worth billions of dollars race to turn CRISPR into a human therapeutic, everyone from prize juries to patent offices to U.S. judges (to, perhaps, Nobel committees) is clashing over who did what when and how important their contribution was. And in a reminder that the patent system lives in its own odd world, a scientist who has won far fewer awards for his CRISPR work, Feng Zhang of the Broad Institute of MIT and Harvard, nevertheless holds the key CRISPR patents, a situation that UC is hotly contesting on behalf of Doudna and Charpentier.

Teams led by that duo and, separately, by Šikšnys first showed that the immune system of bacteria, CRISPR, could be paired with the Cas9 enzyme to alter purified DNA floating outside cells, in test tubes. Their seminal achievement was to show what specific molecular components, including RNA, are necessary to turn CRISPR into a genome-editor.

But bad luck with a journal made Šikšnys the forgotten man of CRISPR: Cell FOOTWEAR Lowtops amp; sneakers Ami aUpjnmfIX
his paper in April 2012 without sending it out for peer review. In contrast, when Doudna, Charpentier, and their colleagues showed that Cas9 could be programmed to cut DNA, their paper sped through the review process at Science and was published online in late June 2012. Šikšnys and his co-authors, meanwhile, had scrambled to find a more receptive journal and landed at Proceedings of the National Academy of Sciences, which published their Womens Superstar 80s 999 W Trainers adidas qKe50O
three months after the Berkeley team’s.

Both groups knew what they had. The Šikšnys team said its findings “pave the way for engineering of universal programmable RNA-guided” DNA-cutting enzymes, while Team Doudna pointed out that CRISPR could be exploited “for RNA-programmable genome editing.’’

That’s only the beginning of the tangled history of CRISPR credit. In early 2013, Harvard biologist George Church and the Broad’s Zhang published simultaneous papers showing that CRISPR can be programmed to cut the genome inside human cells, a step toward turning CRISPR into a disease treatment. By then seemingly everyone had filed for patents, and Zhang, though he filed after Doudna and Charpentier, was awarded foundational CRISPR patents starting in 2014. Those are now the subject of a bitter, years-long, but with any luck almost-at-an-end legal dispute pitting financially strapped UC against the Sale Daiki Leather Heeled Sandals Anthology Paris Anthology Paris JTMJwZ

Since the Broad has won all the legal rounds so far, those rooting for Doudna and Charpentier point to a profound disconnect between law and science: The duo hasalmost run the table of major awards for CRISPR. They shared the 2015 feather strap sandals Black Tom Ford ptbsmW2YF
, the 2015 Gruber Prize in genetics, the 2016 Warren Alpert Prize (with Šikšnys, Rodolphe Barrangou, and Philippe Horvath), and several others. The Kavli nanoscience prize, chosen by a committee of Bardot Midi Dress In Floral Print With Contrast Border Blush Vesper Tall Zajws2BoGb
, is now the latest.

Zhang, in contrast, shared the2016 Gairdner International Award with Doudna and Charpentier and two other scientists for developing CRISPR-Cas “as a genome editing tool for eukaryotic cells.” The trio also shared the 2014 Gabbay Award , the 2016 Tang Prize, and others. Zhang won last year’s Lemelson-MIT award solo.

The Kavli committee bars reporters from contacting the winners, who learned the news only this morning, in advance, or asking CRISPR watchers what they think the latest prize might mean for the prestigious ones awarded every October .



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Cirque Du Soliel KA

Games, links, news, movies, WHATEVER!!! As long as it's not TOO dirty! New to the TPR Forums? Come say hello and introduce yourself HERE!
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by MrMorgan » Thu Jan 05, 2006 5:14 pm

hi. is there anyone out there who has seen KA and has a program with a cast list in it? i'm asking because i saw a promotional video for the show recently, and i'm pretty sure i recognized 2 performers that i've worked with in the past. their names are alvin tam and christian durocher. if anyone has a program, can you look and tell me if they're listed? thanks!

by Real » Thu Jan 05, 2006 6:19 pm

I just want to see KA... Having been to La Nouba I think 3 times and Varekai and Drallion both once, I need some more! Best experience was getting to sit front row to La Nouba...that was crazy. So no, I have no program but I hope I can have one by the end of this year.
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by Neuski » Thu Jan 05, 2006 8:25 pm

I saw KA about two weeks ago, but I don't have a program. As for the show, it was visually impressive, but the continuity of the story needs help. Most of it didn't make much sense.
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by ScOtT k » Thu Jan 05, 2006 9:01 pm

Ka sucked. It was way overrated. If you want a good show in vegas, see mystere or O.
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» Thu Jan 05, 2006 10:57 pm

I've seen a couple of Vegas Shows, including Zumanity and O. Zumanity was not worth the $100.00 price tag, after an hour an a half I was ready to leave. O on the other hand was excellent! If your going to visit Vegas then spend the extra cash and see this show, it's well worth the cost of admission! I'm going back to Vegas in April, and we are planning to see Ka, so I hope it's a good show.
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by SharkTums » Fri Jan 06, 2006 12:16 am

Jeff Kauflin Forbes Staff

Google offers the most prestigious internship program, according to careers site Vault. Krisztian Bocsi/Bloomberg

Many job seekers care deeply about having brand-name companies on their resume, and this urge often surfaces in college, when students begin recruiting for internships. Among the thousands of large companies in the U.S., what internships do students covet the most?

Careers site Vault.com released a ranking of the most prestigious internships. It surveyed roughly 12,000 current and former interns from more than 110 internship programs to answer the question.

To see the top 10 most prestigious internships, open the gallery below. For the full top 20, go to the end of this article.

The 10 Most Prestigious Internships For 2018

11 images

For the third year in a row, Google takes the top spot. The company’s reputation as an attractive workplace with strong talent remains unmatched. “Anyone would hire you after you’ve worked there,” raved one respondent to Vault’s survey. The company is “trustworthy, advanced, always working harder and harder to achieve their goals,” said another Vault user. But that same user felt the company could be more transparent with consumers, presumably about how it uses their information. The user also offered this advice to future interns: “Be ambitious, strong-willed and expect to have to work on one-upping yourself all the time.”

On Vault’s list, Apple and Facebook maintain their second and third-place spots from last year, and Microsoft ranks fourth. Microsoft’s stock has more than doubled since early 2014, when Satya Nadella succeeded Steve Ballmer as CEO. Nadella even released a this year touting the turnaround, titled Hit Refresh: The Quest to Rediscover Microsoft's Soul and Imagine a Better Future for Everyone.

Amazon made a big leap in the ranking, jumping from number 11 last year to seven this year. Americans have developed a sense of awe about Amazon, especially after it purchased Whole Foods and surprised us all with the size of its ambition. Jeff Bezos’ 341,000-person company is recruiting business school students so aggressively that it has become the top MBA recruiter at Duke, Carnegie Mellon and the University of California, Berkeley.

Despite all the buzz about tech companies, finance and consulting firms continue to hold their ground as prestigious places to intern. Three banks made the top 20, including Goldman Sachs (#5), JPMorgan (#8) and Morgan Stanley (#9). Three professional services firms also broke the top 20: PwC (#13), Deloitte (#15) and the Boston Consulting Group (#16).

Full List: The 20 Most Prestigious Internships For 2018

1. Google

2. Apple

3. Facebook

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